ESTROGEN METHYLATION, DETOXIFICATION & METABOLISM
Where Do Estrogens Come From?
Estrogen is a hormone which is made from cholesterol. Typically, estrogen promotes positive effects, supporting tissue growth and female development. This very important hormone has a limited half-life in the metabolism and after completion of its vital function, estrogen must be removed.
The body has a specialized detoxification system for the removal of expired metabolites which includes Phase I and II detoxification reactions.
The methylation of estrogen changes it to an excretable product which is no longer active as a hormone. This crucial methylation step is however often hampered by depletion of essential cofactors and substrates.
There are 3 pathways regarding liver estrogen metabolism of which 2 can lead to potentially carcinogenic products while the other is protective.
What influences which pathway estrogen takes?
1. Low thyroid function
2. Lifestyle and diet habits: B vitamin deficiency (particularly B6) or magnesium, this can reduce the liver's ability to clear estrogen.
Not only do you need to focus on removing carcinogenic metabolites, but also to increase the level of beneficial metabolites.
When 2-hydroxy (2OHE1) estrogen levels increase and is converted to 2-methoxy estrogen (the good metabolites), this is associated with a reduced risk of breast cancer. When there are higher levels of 4 or 16OHE1 (the bad metabolites), there is an increased risk of breast cancer and individuals can experience abnormal growth.
These latter two harmful metabolite, are also associated with obesity, high-fat diets, and exposure to chemicals in one's environment.
By supplementing daily with HORMONE ASSIST, following a healthy, balanced diet and reducing your exposure to chemicals, you can positively influence reduced production of 4 and 16OHE1 (the bad metabolites).
The benefits of Hormone Assist for women
Many health issues ' including fatigue, acne, depression, anxiety, brain fog, mood swings, and weight gain is a result of higher than necessary levels of estrogen or a condition we call 'estrogen dominance.' Estrogen dominance drives the most common hormonal health issues too, from PMS to PCOS. Detoxing your body of excess estrogen has many immediate and long term benefits.
Hormone Assist helps with estrogen dominance and therefore may lessen some of these annoying symptoms, but it may also have protective effects against more serious problems like fibroids, endometriosis and even cancer.
Daily dosage (2 vegetable capsules) contains:
Betaine Anhydrous 98% TMG (Trimethylglycine) 50 mg, Calcium-D-Glucarate 100 mg, Diindolylmethane (DIM) 100 mg, Folic Acid (Vitamin B9) 0,4 mg, Indole-3-Carbinol (I3C) 99% 100 mg, L-Methionine 50 mg Magnesium Glycinate 11,7% (equivalent to elemental value 75 mg) 641 mg, N-Acetyl-L-Cysteine 100 mg, Resveratrol Extract 20-25% (Polygonum Cuspidatum, Root and Rhizome) 180 mg(equivalent to elemental value 45 mg), Vitamin B12 0,1% (Cyanocobalamin) (equivalent to elemental value 100 'g) 10 mg, Vitamin B6 (Pyridoxine Hydrochloride) 10 mg, Zinc amino acid chelate 10% (equivalent to elemental value 3 mg) 30 mg